From SubtiWiki
Revision as of 10:16, 5 December 2012 by Awiechert (talk | contribs)
Jump to: navigation, search
  • Description: valyl-tRNA synthetase

Gene name valS
Essential yes PubMed
Product valyl-tRNA synthetase
Function translation
Gene expression levels in SubtiExpress: valS
Metabolic function and regulation of this protein in SubtiPathways:
tRNA charging, Folate
MW, pI 101 kDa, 4.868
Gene length, protein length 2640 bp, 880 aa
Immediate neighbours folC, yszA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ValS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ValS expression.png

Categories containing this gene/protein

translation, essential genes

This gene is a member of the following regulons


The gene

Basic information

  • Locus tag: BSU28090

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) (according to Swiss-Prot)
  • Protein family: ValS type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1IYW (from Thermus thermophilus, 41% identity, 60% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks



Ana Gutiérrez-Preciado, Tina M Henkin, Frank J Grundy, Charles Yanofsky, Enrique Merino
Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.
Microbiol. Mol. Biol. Rev.: 2009, 73(1);36-61
[PubMed:19258532] [] [DOI] (I p)

Original Publications

D Luo, J Leautey, M Grunberg-Manago, H Putzer
Structure and regulation of expression of the Bacillus subtilis valyl-tRNA synthetase gene.
J. Bacteriol.: 1997, 179(8);2472-8
[PubMed:9098041] [] [DOI] (P p)