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  • Description: prephenate dehydrogenase

Gene name tyrA
Essential no
Product prephenate dehydrogenase
Function biosynthesis of tyrosine
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 41 kDa, 5.471
Gene length, protein length 1113 bp, 371 aa
Immediate neighbours aroE, hisC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
TyrA context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU22610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH (according to Swiss-Prot)
  • Protein family: HisMQ subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


D J Henner, L Band, G Flaggs, E Chen
The organization and nucleotide sequence of the Bacillus subtilis hisH, tyrA and aroE genes.
Gene: 1986, 49(1);147-52
[PubMed:3106153] [WorldCat.org] [DOI] (P p)