SufS

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  • Description: cysteine desulfurase, cysteine:SufU sulfuryl transferase

Gene name sufS
Synonyms yurW, csd
Essential yes PubMed
Product cysteine desulfurase
Function formation of iron-sulfur clusters in proteins
Gene expression levels in SubtiExpress: sufS
Interactions involving this protein in SubtInteract: SufS
MW, pI 44 kDa, 5.199
Gene length, protein length 1218 bp, 406 aa
Immediate neighbours sufU, sufD
Sequences Protein DNA DNA_with_flanks
Genetic context
Csd context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SufS expression.png















Categories containing this gene/protein

iron metabolism, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU32690

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transfer of iron to SufU PubMed
  • Protein family: Csd subfamily (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: interaction with SufU enhances the activity of SufS 40-fold PubMed

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Bruna Selbach, Emily Earles, Patricia C Dos Santos
Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis.
Biochemistry: 2010, 49(40);8794-802
[PubMed:20822158] [WorldCat.org] [DOI] (I p)

Alexander G Albrecht, Daili J A Netz, Marcus Miethke, Antonio J Pierik, Olaf Burghaus, Florian Peuckert, Roland Lill, Mohamed A Marahiel
SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis.
J. Bacteriol.: 2010, 192(6);1643-51
[PubMed:20097860] [WorldCat.org] [DOI] (I p)

Additional publications: PubMed