SufS

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  • Description: cysteine desulfurase

Gene name sufS
Synonyms yurW, csd
Essential yes PubMed
Product cysteine desulfurase
Function formation of iron-sulfur clusters in proteins
MW, pI 44 kDa, 5.199
Gene length, protein length 1218 bp, 406 aa
Immediate neighbours sufU, sufD
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Csd context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

iron metabolism, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU32690

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transfer of iron to SufU PubMed
  • Protein family: Csd subfamily (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: interaction with SufU enhances the activity of SufS 40-fold PubMed
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Bruna Selbach, Emily Earles, Patricia C Dos Santos
Kinetic analysis of the bisubstrate cysteine desulfurase SufS from Bacillus subtilis.
Biochemistry: 2010, 49(40);8794-802
[PubMed:20822158] [WorldCat.org] [DOI] (I p)

Alexander G Albrecht, Daili J A Netz, Marcus Miethke, Antonio J Pierik, Olaf Burghaus, Florian Peuckert, Roland Lill, Mohamed A Marahiel
SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis.
J. Bacteriol.: 2010, 192(6);1643-51
[PubMed:20097860] [WorldCat.org] [DOI] (I p)

Additional publications: PubMed