Difference between revisions of "SpoVAC"

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= [[Categories]] containing this gene/protein =
= [[Categories]] containing this gene/protein =
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=Expression and regulation=
=Expression and regulation=
* '''Operon:''' ''[[spoVAA]]-[[spoVAB]]-[[spoVAC]]-[[spoVAD]]-[[spoVAE]]-[[spoVAF]]-[[lysA]]'' {{PubMed|7934830}}
* '''Operon:''' ''[[spoVAA]]-[[spoVAB]]-[[spoVAC]]-[[spoVAD]]-[[spoVAEB]]-[[spoVAEA]]-[[spoVAF]]-[[lysA]]'' {{PubMed|7934830}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoVAC_2441804_2442256_-1 spoVAC] {{PubMed|22383849}}
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=spoVAC_2441804_2442256_-1 spoVAC] {{PubMed|22383849}}
* '''Sigma factor:''' [[SigG]] {{PubMed|15699190,1903432}}
* '''[[Sigma factor]]:''' [[SigG]] {{PubMed|15699190,1903432}}
* '''Regulation:'''  
* '''Regulation:'''  

Revision as of 17:35, 25 January 2013

  • Description: essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing spores, required for spore maturation

Gene name spoVAC
Essential no
Product unknown
Function spore maturation
Gene expression levels in SubtiExpress: spoVAC
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr
MW, pI 15 kDa, 9.461
Gene length, protein length 450 bp, 150 aa
Immediate neighbours spoVAD, spoVAB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SpoVAC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoVAC expression.png

Categories containing this gene/protein

sporulation proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

  • Locus tag: BSU23420

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Yunfeng Li, Andrew Davis, George Korza, Pengfei Zhang, Yong-qing Li, Barbara Setlow, Peter Setlow, Bing Hao
Role of a SpoVA protein in dipicolinic acid uptake into developing spores of Bacillus subtilis.
J. Bacteriol.: 2012, 194(8);1875-84
[PubMed:22328679] [WorldCat.org] [DOI] (I p)

Venkata Ramana Vepachedu, Peter Setlow
Role of SpoVA proteins in release of dipicolinic acid during germination of Bacillus subtilis spores triggered by dodecylamine or lysozyme.
J. Bacteriol.: 2007, 189(5);1565-72
[PubMed:17158659] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading, Engl.): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Venkata Ramana Vepachedu, Peter Setlow
Analysis of the germination of spores of Bacillus subtilis with temperature sensitive spo mutations in the spoVA operon.
FEMS Microbiol. Lett.: 2004, 239(1);71-7
[PubMed:15451103] [WorldCat.org] [DOI] (P p)

Federico Tovar-Rojo, Monica Chander, Barbara Setlow, Peter Setlow
The products of the spoVA operon are involved in dipicolinic acid uptake into developing spores of Bacillus subtilis.
J. Bacteriol.: 2002, 184(2);584-7
[PubMed:11751839] [WorldCat.org] [DOI] (P p)

I Bagyan, J Hobot, S Cutting
A compartmentalized regulator of developmental gene expression in Bacillus subtilis.
J. Bacteriol.: 1996, 178(15);4500-7
[PubMed:8755877] [WorldCat.org] [DOI] (P p)

V Azevedo, A Sorokin, S D Ehrlich, P Serror
The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci.
Mol. Microbiol.: 1993, 10(2);397-405
[PubMed:7934830] [WorldCat.org] [DOI] (P p)

B Moldover, P J Piggot, M D Yudkin
Identification of the promoter and the transcriptional start site of the spoVA operon of Bacillus subtilis and Bacillus licheniformis.
J. Gen. Microbiol.: 1991, 137(3);527-31
[PubMed:1903432] [WorldCat.org] [DOI] (P p)

J Errington, J Mandelstam
Use of a lacZ gene fusion to determine the dependence pattern and the spore compartment expression of sporulation operon spoVA in spo mutants of Bacillus subtilis.
J. Gen. Microbiol.: 1986, 132(11);2977-85
[PubMed:3114420] [WorldCat.org] [DOI] (P p)

P Fort, J Errington
Nucleotide sequence and complementation analysis of a polycistronic sporulation operon, spoVA, in Bacillus subtilis.
J. Gen. Microbiol.: 1985, 131(5);1091-105
[PubMed:3926949] [WorldCat.org] [DOI] (P p)

J Errington, J Mandelstam
Genetic and phenotypic characterization of a cluster of mutations in the spoVA locus of Bacillus subtilis.
J. Gen. Microbiol.: 1984, 130(8);2115-21
[PubMed:6432957] [WorldCat.org] [DOI] (P p)