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  • Description: mechanosensitive channel, essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing spores, required for spore maturation

Gene name spoVAC
Essential no
Product mechanosensitive channel
Function spore maturation
Gene expression levels in SubtiExpress: spoVAC
Metabolic function and regulation of this protein in SubtiPathways:
MW, pI 15 kDa, 9.461
Gene length, protein length 450 bp, 150 aa
Immediate neighbours spoVAD, spoVAB
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoVAC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoVAC expression.png

Categories containing this gene/protein

sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigG regulon, SpoVT regulon

The gene

Basic information

  • Locus tag: BSU23420

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Jeanette Velásquez, Gea Schuurman-Wolters, Jan Peter Birkner, Tjakko Abee, Bert Poolman
Bacillus subtilis spore protein SpoVAC functions as a mechanosensitive channel.
Mol. Microbiol.: 2014, 92(4);813-23
[PubMed:24666282] [WorldCat.org] [DOI] (I p)

Yunfeng Li, Andrew Davis, George Korza, Pengfei Zhang, Yong-qing Li, Barbara Setlow, Peter Setlow, Bing Hao
Role of a SpoVA protein in dipicolinic acid uptake into developing spores of Bacillus subtilis.
J. Bacteriol.: 2012, 194(8);1875-84
[PubMed:22328679] [WorldCat.org] [DOI] (I p)

Guiwen Wang, Xuan Yi, Yong-qing Li, Peter Setlow
Germination of individual Bacillus subtilis spores with alterations in the GerD and SpoVA proteins, which are important in spore germination.
J. Bacteriol.: 2011, 193(9);2301-11
[PubMed:21398556] [WorldCat.org] [DOI] (I p)

Venkata Ramana Vepachedu, Peter Setlow
Role of SpoVA proteins in release of dipicolinic acid during germination of Bacillus subtilis spores triggered by dodecylamine or lysozyme.
J. Bacteriol.: 2007, 189(5);1565-72
[PubMed:17158659] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading, Engl.): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Venkata Ramana Vepachedu, Peter Setlow
Analysis of the germination of spores of Bacillus subtilis with temperature sensitive spo mutations in the spoVA operon.
FEMS Microbiol. Lett.: 2004, 239(1);71-7
[PubMed:15451103] [WorldCat.org] [DOI] (P p)

Federico Tovar-Rojo, Monica Chander, Barbara Setlow, Peter Setlow
The products of the spoVA operon are involved in dipicolinic acid uptake into developing spores of Bacillus subtilis.
J. Bacteriol.: 2002, 184(2);584-7
[PubMed:11751839] [WorldCat.org] [DOI] (P p)

I Bagyan, J Hobot, S Cutting
A compartmentalized regulator of developmental gene expression in Bacillus subtilis.
J. Bacteriol.: 1996, 178(15);4500-7
[PubMed:8755877] [WorldCat.org] [DOI] (P p)

V Azevedo, A Sorokin, S D Ehrlich, P Serror
The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci.
Mol. Microbiol.: 1993, 10(2);397-405
[PubMed:7934830] [WorldCat.org] [DOI] (P p)

B Moldover, P J Piggot, M D Yudkin
Identification of the promoter and the transcriptional start site of the spoVA operon of Bacillus subtilis and Bacillus licheniformis.
J. Gen. Microbiol.: 1991, 137(3);527-31
[PubMed:1903432] [WorldCat.org] [DOI] (P p)

J Errington, J Mandelstam
Use of a lacZ gene fusion to determine the dependence pattern and the spore compartment expression of sporulation operon spoVA in spo mutants of Bacillus subtilis.
J. Gen. Microbiol.: 1986, 132(11);2977-85
[PubMed:3114420] [WorldCat.org] [DOI] (P p)

P Fort, J Errington
Nucleotide sequence and complementation analysis of a polycistronic sporulation operon, spoVA, in Bacillus subtilis.
J. Gen. Microbiol.: 1985, 131(5);1091-105
[PubMed:3926949] [WorldCat.org] [DOI] (P p)

J Errington, J Mandelstam
Genetic and phenotypic characterization of a cluster of mutations in the spoVA locus of Bacillus subtilis.
J. Gen. Microbiol.: 1984, 130(8);2115-21
[PubMed:6432957] [WorldCat.org] [DOI] (P p)