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  • Description: serine protease, cleaves SpoIVFA, this results in pro-sigma-K processing/activation in the mother-cell, does also cleave CtpB

Gene name spoIVB
Essential no
Product serine protease
Function control of SigK activation
MW, pI 45 kDa, 8.842
Gene length, protein length 1275 bp, 425 aa
Immediate neighbours spo0A, recN
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SpoIVB context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU24230

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation: expressed during sporulation in the forespore (SigF, SigG) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Simon Cutting, London, UK homepage

Your additional remarks