Difference between revisions of "Spo0A"

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(Other original Publications)
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==Other original Publications==
 
==Other original Publications==
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<pubmed>14679239, 1569009 20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139, 12067336, 10869437, 16385044,9287005, 8127878, 9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522, 16166384, 9495766,2118512, 1556084, 18296515,7768874, 3145384, 19114652 20689749  1537790,9658000, 8509330,14762002, 1846779, 2981817, 9477965,8600030, 18840696, 1391039, 14976210, 19207565 11679073 12270811 11112444 18978066 20154131 14712656 17157871 15060025 9685500 10852876 21552330  22303282 22745669 23301687 23335417 23660663 25225273  25341802 26152584 23012477,23170957, 23169620,22412392, 21326214,21435029, 21478340,21622736, 21949067, 21980382,22211522 23927765 24123822 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:03, 13 July 2015

Gene name spo0A
Synonyms spo0C, spo0G, spoIIL, sof-1
Essential no
Product phosphorelay response regulator
Function initiation of sporulation
Gene expression levels in SubtiExpress: spo0A
Interactions involving this protein in SubtInteract: Spo0A
Metabolic function and regulation of this protein in SubtiPathways:
spo0A
MW, pI 29 kDa, 5.989
Gene length, protein length 801 bp, 267 aa
Immediate neighbours yqiG, spoIVB
Sequences Protein DNA DNA_with_flanks
Genetic context
Spo0A context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Spo0A expression.png















Categories containing this gene/protein

transcription factors and their control, phosphorelay, biofilm formation, phosphoproteins

This gene is a member of the following regulons

SigH regulon, Spo0A regulon

The Spo0A regulon

The gene

Basic information

  • Locus tag: BSU24220

Phenotypes of a mutant

  • inactivation of spo0A restores beta-lactam resistance in a sigM mutant PubMed
  • altered cell death pattern in colonies PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
  • Cofactor(s):
  • Effectors of protein activity:
    • the phosphorylation state affects DNA binding activity
    • interaction with MecA inhibits the transcriptional activity of Spo0A∼P PubMed

Database entries

  • Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed by casamino acids PubMed
    • repressed by SinR overexpression PubMed
    • repressed by soj PubMed
    • expression increases when drowth rate declines PubMed
  • Regulatory mechanism:
    • Spo0A: transcription repression PubMed
    • Spo0A synthesis is subject to a post-transcriptional control mechanism such that translation of mRNAs originating from the SigA-dependent promoter is impeded due to RNA secondary structure PubMed
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium, exponential phase): 394 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, early stationary phase after glucose exhaustion): 358 PubMed
    • number of protein molecules per cell (minimal medium with glucose and ammonium, late stationary phase after glucose exhaustion): 1763 PubMed

Biological materials

  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Marcin Wolański, Dagmara Jakimowicz, Jolanta Zakrzewska-Czerwińska
Fifty years after the replicon hypothesis: cell-specific master regulators as new players in chromosome replication control.
J. Bacteriol.: 2014, 196(16);2901-11
[PubMed:24914187] [WorldCat.org] [DOI] (I p)

Liza Gross
Built-in timer delays differentiation.
PLoS Biol.: 2012, 10(1);e1001254
[PubMed:22303284] [WorldCat.org] [DOI] (I p)

José Eduardo González-Pastor
Cannibalism: a social behavior in sporulating Bacillus subtilis.
FEMS Microbiol. Rev.: 2011, 35(3);415-24
[PubMed:20955377] [WorldCat.org] [DOI] (I p)

Michiel J L de Hoon, Patrick Eichenberger, Dennis Vitkup
Hierarchical evolution of the bacterial sporulation network.
Curr. Biol.: 2010, 20(17);R735-45
[PubMed:20833318] [WorldCat.org] [DOI] (I p)

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat. Rev. Microbiol.: 2010, 8(3);163-70
[PubMed:20157337] [WorldCat.org] [DOI] (I p)

Daniel López, Roberto Kolter
Extracellular signals that define distinct and coexisting cell fates in Bacillus subtilis.
FEMS Microbiol. Rev.: 2010, 34(2);134-49
[PubMed:20030732] [WorldCat.org] [DOI] (I p)

Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A.: 2009, 106(50);21027-34
[PubMed:19995980] [WorldCat.org] [DOI] (I p)

S Seredick, G B Spiegelman
Lessons and questions from the structure of the Spo0A activation domain.
Trends Microbiol.: 2001, 9(4);148-51
[PubMed:11286862] [WorldCat.org] [DOI] (P p)


The Spo0A regulon

Masaya Fujita, José Eduardo González-Pastor, Richard Losick
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.
J. Bacteriol.: 2005, 187(4);1357-68
[PubMed:15687200] [WorldCat.org] [DOI] (P p)

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol. Microbiol.: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)

Other original Publications

Roberto R Grau, Paula de Oña, Maritta Kunert, Cecilia Leñini, Ramses Gallegos-Monterrosa, Eisha Mhatre, Darío Vileta, Verónica Donato, Theresa Hölscher, Wilhelm Boland, Oscar P Kuipers, Ákos T Kovács
A Duo of Potassium-Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis.
mBio: 2015, 6(4);e00581
[PubMed:26152584] [WorldCat.org] [DOI] (I e)

Adaoha E C Ihekwaba, Ivan Mura, Gary C Barker
Computational modelling and analysis of the molecular network regulating sporulation initiation in Bacillus subtilis.
BMC Syst Biol: 2014, 8;119
[PubMed:25341802] [WorldCat.org] [DOI] (I e)

Cláudia R Serra, Ashlee M Earl, Teresa M Barbosa, Roberto Kolter, Adriano O Henriques
Sporulation during growth in a gut isolate of Bacillus subtilis.
J. Bacteriol.: 2014, 196(23);4184-96
[PubMed:25225273] [WorldCat.org] [DOI] (I p)

Victoria L Marlow, Michael Porter, Laura Hobley, Taryn B Kiley, Jason R Swedlow, Fordyce A Davidson, Nicola R Stanley-Wall
Phosphorylated DegU manipulates cell fate differentiation in the Bacillus subtilis biofilm.
J. Bacteriol.: 2014, 196(1);16-27
[PubMed:24123822] [WorldCat.org] [DOI] (I p)

Monika Vishnoi, Jatin Narula, Seram Nganbiton Devi, Hoang-Anh Dao, Oleg A Igoshin, Masaya Fujita
Triggering sporulation in Bacillus subtilis with artificial two-component systems reveals the importance of proper Spo0A activation dynamics.
Mol. Microbiol.: 2013, 90(1);181-94
[PubMed:23927765] [WorldCat.org] [DOI] (I p)

Monica Gupta, Madhulika Dixit, K Krishnamurthy Rao
Spo0A positively regulates epr expression by negating the repressive effect of co-repressors, SinR and ScoC, in Bacillus subtilis.
J. Biosci.: 2013, 38(2);291-9
[PubMed:23660663] [WorldCat.org] [DOI] (I p)

Sharon Garti-Levi, Ashlee Eswara, Yoav Smith, Masaya Fujita, Sigal Ben-Yehuda
Novel modulators controlling entry into sporulation in Bacillus subtilis.
J. Bacteriol.: 2013, 195(7);1475-83
[PubMed:23335417] [WorldCat.org] [DOI] (I p)

Mirjam Boonstra, Imke G de Jong, Graham Scholefield, Heath Murray, Oscar P Kuipers, Jan-Willem Veening
Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis.
Mol. Microbiol.: 2013, 87(4);925-38
[PubMed:23301687] [WorldCat.org] [DOI] (I p)

María E Pedrido, Paula de Oña, Walter Ramirez, Cecilia Leñini, Anibal Goñi, Roberto Grau
Spo0A links de novo fatty acid synthesis to sporulation and biofilm development in Bacillus subtilis.
Mol. Microbiol.: 2013, 87(2);348-67
[PubMed:23170957] [WorldCat.org] [DOI] (I p)

Jatin Narula, Seram N Devi, Masaya Fujita, Oleg A Igoshin
Ultrasensitivity of the Bacillus subtilis sporulation decision.
Proc. Natl. Acad. Sci. U.S.A.: 2012, 109(50);E3513-22
[PubMed:23169620] [WorldCat.org] [DOI] (I p)

Munehiro Asally, Mark Kittisopikul, Pau Rué, Yingjie Du, Zhenxing Hu, Tolga Çağatay, Andra B Robinson, Hongbing Lu, Jordi Garcia-Ojalvo, Gürol M Süel
Localized cell death focuses mechanical forces during 3D patterning in a biofilm.
Proc. Natl. Acad. Sci. U.S.A.: 2012, 109(46);18891-6
[PubMed:23012477] [WorldCat.org] [DOI] (I p)

Fordyce A Davidson, Chung Seon-Yi, Nicola R Stanley-Wall
Selective heterogeneity in exoprotease production by Bacillus subtilis.
PLoS ONE: 2012, 7(6);e38574
[PubMed:22745669] [WorldCat.org] [DOI] (I p)

Nicolas Mirouze, Yaanik Desai, Arjun Raj, David Dubnau
Spo0A~P imposes a temporal gate for the bimodal expression of competence in Bacillus subtilis.
PLoS Genet.: 2012, 8(3);e1002586
[PubMed:22412392] [WorldCat.org] [DOI] (I p)

Joe H Levine, Michelle E Fontes, Jonathan Dworkin, Michael B Elowitz
Pulsed feedback defers cellular differentiation.
PLoS Biol.: 2012, 10(1);e1001252
[PubMed:22303282] [WorldCat.org] [DOI] (I p)

Yun Luo, John D Helmann
Analysis of the role of Bacillus subtilis σ(M) in β-lactam resistance reveals an essential role for c-di-AMP in peptidoglycan homeostasis.
Mol. Microbiol.: 2012, 83(3);623-39
[PubMed:22211522] [WorldCat.org] [DOI] (I p)

Shaunak Sen, Jordi Garcia-Ojalvo, Michael B Elowitz
Dynamical consequences of bandpass feedback loops in a bacterial phosphorelay.
PLoS ONE: 2011, 6(9);e25102
[PubMed:21980382] [WorldCat.org] [DOI] (I p)

Arnaud Chastanet, Richard Losick
Just-in-time control of Spo0A synthesis in Bacillus subtilis by multiple regulatory mechanisms.
J. Bacteriol.: 2011, 193(22);6366-74
[PubMed:21949067] [WorldCat.org] [DOI] (I p)

Allison V Banse, Errett C Hobbs, Richard Losick
Phosphorylation of Spo0A by the histidine kinase KinD requires the lipoprotein med in Bacillus subtilis.
J. Bacteriol.: 2011, 193(15);3949-55
[PubMed:21622736] [WorldCat.org] [DOI] (I p)

Nicolas Mirouze, Peter Prepiak, David Dubnau
Fluctuations in spo0A transcription control rare developmental transitions in Bacillus subtilis.
PLoS Genet.: 2011, 7(4);e1002048
[PubMed:21552330] [WorldCat.org] [DOI] (I p)

Panagiotis Xenopoulos, Patrick J Piggot
Regulation of growth of the mother cell and chromosome replication during sporulation of Bacillus subtilis.
J. Bacteriol.: 2011, 193(12);3117-26
[PubMed:21478340] [WorldCat.org] [DOI] (I p)

Peter Prepiak, Melissa Defrancesco, Sophia Spadavecchia, Nicolas Mirouze, Mark Albano, Marjan Persuh, Masaya Fujita, D Dubnau
MecA dampens transitions to spore, biofilm exopolysaccharide and competence expression by two different mechanisms.
Mol. Microbiol.: 2011, 80(4);1014-30
[PubMed:21435029] [WorldCat.org] [DOI] (I p)

Yunrong Chai, Thomas Norman, Roberto Kolter, Richard Losick
Evidence that metabolism and chromosome copy number control mutually exclusive cell fates in Bacillus subtilis.
EMBO J.: 2011, 30(7);1402-13
[PubMed:21326214] [WorldCat.org] [DOI] (I p)

Claudio Aguilar, Hera Vlamakis, Alejandra Guzman, Richard Losick, Roberto Kolter
KinD is a checkpoint protein linking spore formation to extracellular-matrix production in Bacillus subtilis biofilms.
mBio: 2010, 1(1);
[PubMed:20689749] [WorldCat.org] [DOI] (I e)

Prahathees Eswaramoorthy, Jeffrey Dinh, Daniel Duan, Oleg A Igoshin, Masaya Fujita
Single-cell measurement of the levels and distributions of the phosphorelay components in a population of sporulating Bacillus subtilis cells.
Microbiology (Reading): 2010, 156(Pt 8);2294-2304
[PubMed:20413551] [WorldCat.org] [DOI] (I p)

Arnaud Chastanet, Dennis Vitkup, Guo-Cheng Yuan, Thomas M Norman, Jun S Liu, Richard M Losick
Broadly heterogeneous activation of the master regulator for sporulation in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A.: 2010, 107(18);8486-91
[PubMed:20404177] [WorldCat.org] [DOI] (I p)

Imke G de Jong, Jan-Willem Veening, Oscar P Kuipers
Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.
J. Bacteriol.: 2010, 192(8);2053-67
[PubMed:20154131] [WorldCat.org] [DOI] (I p)

Steve D Seredick, Barbara M Seredick, David Baker, George B Spiegelman
An A257V mutation in the bacillus subtilis response regulator Spo0A prevents regulated expression of promoters with low-consensus binding sites.
J. Bacteriol.: 2009, 191(17);5489-98
[PubMed:19581368] [WorldCat.org] [DOI] (I p)

Virginia Castilla-Llorente, Wilfried J J Meijer, Margarita Salas
Differential Spo0A-mediated effects on transcription and replication of the related Bacillus subtilis phages Nf and phi29 explain their different behaviours in vivo.
Nucleic Acids Res.: 2009, 37(15);4955-64
[PubMed:19528067] [WorldCat.org] [DOI] (I p)

Virginia Castilla-Llorente, Margarita Salas, Wilfried J J Meijer
Different responses to Spo0A-mediated suppression of the related Bacillus subtilis phages Nf and phi29.
Environ. Microbiol.: 2009, 11(5);1137-49
[PubMed:19207565] [WorldCat.org] [DOI] (I p)

Daniel López, Michael A Fischbach, Frances Chu, Richard Losick, Roberto Kolter
Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A.: 2009, 106(1);280-5
[PubMed:19114652] [WorldCat.org] [DOI] (I p)

Daniel T Verhamme, Ewan J Murray, Nicola R Stanley-Wall
DegU and Spo0A jointly control transcription of two loci required for complex colony development by Bacillus subtilis.
J. Bacteriol.: 2009, 191(1);100-8
[PubMed:18978066] [WorldCat.org] [DOI] (I p)

Allison V Banse, Arnaud Chastanet, Lilah Rahn-Lee, Errett C Hobbs, Richard Losick
Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A.: 2008, 105(40);15547-52
[PubMed:18840696] [WorldCat.org] [DOI] (I p)

Amrita Kumar, Charles P Moran
Promoter activation by repositioning of RNA polymerase.
J. Bacteriol.: 2008, 190(9);3110-7
[PubMed:18296515] [WorldCat.org] [DOI] (I p)

Steve D Seredick, George B Spiegelman
Bacillus subtilis RNA polymerase recruits the transcription factor Spo0A approximately P to stabilize a closed complex during transcription initiation.
J. Mol. Biol.: 2007, 366(1);19-35
[PubMed:17157871] [WorldCat.org] [DOI] (P p)

Guangnan Chen, Amrita Kumar, Travis H Wyman, Charles P Moran
Spo0A-dependent activation of an extended -10 region promoter in Bacillus subtilis.
J. Bacteriol.: 2006, 188(4);1411-8
[PubMed:16452424] [WorldCat.org] [DOI] (P p)

Jessica M Silvaggi, John B Perkins, Richard Losick
Genes for small, noncoding RNAs under sporulation control in Bacillus subtilis.
J. Bacteriol.: 2006, 188(2);532-41
[PubMed:16385044] [WorldCat.org] [DOI] (P p)

Masaya Fujita, Richard Losick
Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A.
Genes Dev.: 2005, 19(18);2236-44
[PubMed:16166384] [WorldCat.org] [DOI] (P p)

Ulrike Mäder, Susanne Hennig, Michael Hecker, Georg Homuth
Transcriptional organization and posttranscriptional regulation of the Bacillus subtilis branched-chain amino acid biosynthesis genes.
J. Bacteriol.: 2004, 186(8);2240-52
[PubMed:15060025] [WorldCat.org] [DOI] (P p)

Steve D Seredick, George B Spiegelman
The Bacillus subtilis response regulator Spo0A stimulates sigmaA-dependent transcription prior to the major energetic barrier.
J. Biol. Chem.: 2004, 279(17);17397-403
[PubMed:14976210] [WorldCat.org] [DOI] (P p)

Amrita Kumar, James A Brannigan, Charles P Moran
Alpha-helix E of Spo0A is required for sigmaA- but not for sigmaH-dependent promoter activation in Bacillus subtilis.
J. Bacteriol.: 2004, 186(4);1078-83
[PubMed:14762002] [WorldCat.org] [DOI] (P p)

Steve D Seredick, Barbara M Turner, George B Spiegelman
Assay of transcription modulation by SpoOA of Bacillus subtilis.
Meth. Enzymol.: 2003, 370;312-23
[PubMed:14712656] [WorldCat.org] [DOI] (P p)

Amrita Kumar, Cindy Buckner Starke, Mark DeZalia, Charles P Moran
Surfaces of Spo0A and RNA polymerase sigma factor A that interact at the spoIIG promoter in Bacillus subtilis.
J. Bacteriol.: 2004, 186(1);200-6
[PubMed:14679239] [WorldCat.org] [DOI] (P p)

Masaya Fujita, Richard Losick
The master regulator for entry into sporulation in Bacillus subtilis becomes a cell-specific transcription factor after asymmetric division.
Genes Dev.: 2003, 17(9);1166-74
[PubMed:12730135] [WorldCat.org] [DOI] (P p)

Shigeo Hosoya, Kei Asai, Naotake Ogasawara, Michio Takeuchi, Tsutomu Sato
Mutation in yaaT leads to significant inhibition of phosphorelay during sporulation in Bacillus subtilis.
J. Bacteriol.: 2002, 184(20);5545-53
[PubMed:12270811] [WorldCat.org] [DOI] (P p)

Haiyan Zhao, Tarek Msadek, James Zapf, Madhusudan, James A Hoch, Kottayil I Varughese
DNA complexed structure of the key transcription factor initiating development in sporulating bacteria.
Structure: 2002, 10(8);1041-50
[PubMed:12176382] [WorldCat.org] [DOI] (P p)

Sophie J Stephenson, Marta Perego
Interaction surface of the Spo0A response regulator with the Spo0E phosphatase.
Mol. Microbiol.: 2002, 44(6);1455-67
[PubMed:12067336] [WorldCat.org] [DOI] (P p)

M Perego
A new family of aspartyl phosphate phosphatases targeting the sporulation transcription factor Spo0A of Bacillus subtilis.
Mol. Microbiol.: 2001, 42(1);133-43
[PubMed:11679073] [WorldCat.org] [DOI] (P p)

C Eymann, G Mittenhuber, M Hecker
The stringent response, sigmaH-dependent gene expression and sporulation in Bacillus subtilis.
Mol. Gen. Genet.: 2001, 264(6);913-23
[PubMed:11254139] [WorldCat.org] [DOI] (P p)

H Nanamiya, K Takahashi, M Fujita, F Kawamura
Deficiency of the initiation events of sporulation in Bacillus subtilis clpP mutant can be suppressed by a lack of the Spo0E protein phosphatase.
Biochem. Biophys. Res. Commun.: 2000, 279(1);229-33
[PubMed:11112444] [WorldCat.org] [DOI] (P p)

M Jiang, W Shao, M Perego, J A Hoch
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
Mol. Microbiol.: 2000, 38(3);535-42
[PubMed:11069677] [WorldCat.org] [DOI] (P p)

P Fawcett, P Eichenberger, R Losick, P Youngman
The transcriptional profile of early to middle sporulation in Bacillus subtilis.
Proc. Natl. Acad. Sci. U.S.A.: 2000, 97(14);8063-8
[PubMed:10869437] [WorldCat.org] [DOI] (P p)

J D Quisel, A D Grossman
Control of sporulation gene expression in Bacillus subtilis by the chromosome partitioning proteins Soj (ParA) and Spo0J (ParB).
J. Bacteriol.: 2000, 182(12);3446-51
[PubMed:10852876] [WorldCat.org] [DOI] (P p)

C M Buckner, C P Moran
A region in Bacillus subtilis sigmaH required for Spo0A-dependent promoter activity.
J. Bacteriol.: 1998, 180(18);4987-90
[PubMed:9733708] [WorldCat.org] [DOI] (P p)

M A Cervin, R J Lewis, J A Brannigan, G B Spiegelman
The Bacillus subtilis regulator SinR inhibits spoIIG promoter transcription in vitro without displacing RNA polymerase.
Nucleic Acids Res.: 1998, 26(16);3806-12
[PubMed:9685500] [WorldCat.org] [DOI] (P p)

C M Buckner, G Schyns, C P Moran
A region in the Bacillus subtilis transcription factor Spo0A that is important for spoIIG promoter activation.
J. Bacteriol.: 1998, 180(14);3578-83
[PubMed:9658000] [WorldCat.org] [DOI] (P p)

A Khvorova, L Zhang, M L Higgins, P J Piggot
The spoIIE locus is involved in the Spo0A-dependent switch in the location of FtsZ rings in Bacillus subtilis.
J. Bacteriol.: 1998, 180(5);1256-60
[PubMed:9495766] [WorldCat.org] [DOI] (P p)

C E Grimshaw, S Huang, C G Hanstein, M A Strauch, D Burbulys, L Wang, J A Hoch, J M Whiteley
Synergistic kinetic interactions between components of the phosphorelay controlling sporulation in Bacillus subtilis.
Biochemistry: 1998, 37(5);1365-75
[PubMed:9477965] [WorldCat.org] [DOI] (P p)

G Schyns, C M Buckner, C P Moran
Activation of the Bacillus subtilis spoIIG promoter requires interaction of Spo0A and the sigma subunit of RNA polymerase.
J. Bacteriol.: 1997, 179(17);5605-8
[PubMed:9287022] [WorldCat.org] [DOI] (P p)

L V Wray, A E Ferson, S H Fisher
Expression of the Bacillus subtilis ureABC operon is controlled by multiple regulatory factors including CodY, GlnR, TnrA, and Spo0H.
J. Bacteriol.: 1997, 179(17);5494-501
[PubMed:9287005] [WorldCat.org] [DOI] (P p)

M Perego, P Glaser, J A Hoch
Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis.
Mol. Microbiol.: 1996, 19(6);1151-7
[PubMed:8730857] [WorldCat.org] [DOI] (P p)

P A Levin, R Losick
Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis.
Genes Dev.: 1996, 10(4);478-88
[PubMed:8600030] [WorldCat.org] [DOI] (P p)

J Hahn, M Roggiani, D Dubnau
The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.
J. Bacteriol.: 1995, 177(12);3601-5
[PubMed:7768874] [WorldCat.org] [DOI] (P p)

J K Grimsley, R B Tjalkens, M A Strauch, T H Bird, G B Spiegelman, Z Hostomsky, J M Whiteley, J A Hoch
Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis.
J. Biol. Chem.: 1994, 269(24);16977-82
[PubMed:8207022] [WorldCat.org] (P p)

K L Ohlsen, J K Grimsley, J A Hoch
Deactivation of the sporulation transcription factor Spo0A by the Spo0E protein phosphatase.
Proc. Natl. Acad. Sci. U.S.A.: 1994, 91(5);1756-60
[PubMed:8127878] [WorldCat.org] [DOI] (P p)

J M Baldus, B D Green, P Youngman, C P Moran
Phosphorylation of Bacillus subtilis transcription factor Spo0A stimulates transcription from the spoIIG promoter by enhancing binding to weak 0A boxes.
J. Bacteriol.: 1994, 176(2);296-306
[PubMed:8288522] [WorldCat.org] [DOI] (P p)

T H Bird, J K Grimsley, J A Hoch, G B Spiegelman
Phosphorylation of Spo0A activates its stimulation of in vitro transcription from the Bacillus subtilis spoIIG operon.
Mol. Microbiol.: 1993, 9(4);741-9
[PubMed:8231806] [WorldCat.org] [DOI] (P p)

K K Jensen, E Sharkova, M F Duggan, Y Qi, A Koide, J A Hoch, F M Hulett
Bacillus subtilis transcription regulator, Spo0A, decreases alkaline phosphatase levels induced by phosphate starvation.
J. Bacteriol.: 1993, 175(12);3749-56
[PubMed:8509330] [WorldCat.org] [DOI] (P p)

M A Strauch, K A Trach, J Day, J A Hoch
Spo0A activates and represses its own synthesis by binding at its dual promoters.
Biochimie: 1992, 74(7-8);619-26
[PubMed:1391039] [WorldCat.org] [DOI] (P p)

M Predich, G Nair, I Smith
Bacillus subtilis early sporulation genes kinA, spo0F, and spo0A are transcribed by the RNA polymerase containing sigma H.
J. Bacteriol.: 1992, 174(9);2771-8
[PubMed:1569009] [WorldCat.org] [DOI] (P p)

K York, T J Kenney, S Satola, C P Moran, H Poth, P Youngman
Spo0A controls the sigma A-dependent activation of Bacillus subtilis sporulation-specific transcription unit spoIIE.
J. Bacteriol.: 1992, 174(8);2648-58
[PubMed:1556084] [WorldCat.org] [DOI] (P p)

S W Satola, J M Baldus, C P Moran
Binding of Spo0A stimulates spoIIG promoter activity in Bacillus subtilis.
J. Bacteriol.: 1992, 174(5);1448-53
[PubMed:1537790] [WorldCat.org] [DOI] (P p)

M Perego, J J Wu, G B Spiegelman, J A Hoch
Mutational dissociation of the positive and negative regulatory properties of the Spo0A sporulation transcription factor of Bacillus subtilis.
Gene: 1991, 100;207-12
[PubMed:1905258] [WorldCat.org] [DOI] (P p)

D Burbulys, K A Trach, J A Hoch
Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay.
Cell: 1991, 64(3);545-52
[PubMed:1846779] [WorldCat.org] [DOI] (P p)

U Bai, M Lewandoski, E Dubnau, I Smith
Temporal regulation of the Bacillus subtilis early sporulation gene spo0F.
J. Bacteriol.: 1990, 172(9);5432-9
[PubMed:2118512] [WorldCat.org] [DOI] (P p)

G Spiegelman, B Van Hoy, M Perego, J Day, K Trach, J A Hoch
Structural alterations in the Bacillus subtilis Spo0A regulatory protein which suppress mutations at several spo0 loci.
J. Bacteriol.: 1990, 172(9);5011-9
[PubMed:2118505] [WorldCat.org] [DOI] (P p)

M Strauch, V Webb, G Spiegelman, J A Hoch
The SpoOA protein of Bacillus subtilis is a repressor of the abrB gene.
Proc. Natl. Acad. Sci. U.S.A.: 1990, 87(5);1801-5
[PubMed:2106683] [WorldCat.org] [DOI] (P p)

M Perego, G B Spiegelman, J A Hoch
Structure of the gene for the transition state regulator, abrB: regulator synthesis is controlled by the spo0A sporulation gene in Bacillus subtilis.
Mol. Microbiol.: 1988, 2(6);689-99
[PubMed:3145384] [WorldCat.org] [DOI] (P p)

P Zuber, R Losick
Role of AbrB in Spo0A- and Spo0B-dependent utilization of a sporulation promoter in Bacillus subtilis.
J. Bacteriol.: 1987, 169(5);2223-30
[PubMed:2437099] [WorldCat.org] [DOI] (P p)

F A Ferrari, K Trach, D LeCoq, J Spence, E Ferrari, J A Hoch
Characterization of the spo0A locus and its deduced product.
Proc. Natl. Acad. Sci. U.S.A.: 1985, 82(9);2647-51
[PubMed:3157992] [WorldCat.org] [DOI] (P p)

J A Hoch, K Trach, F Kawamura, H Saito
Identification of the transcriptional suppressor sof-1 as an alteration in the spo0A protein.
J. Bacteriol.: 1985, 161(2);552-5
[PubMed:2981817] [WorldCat.org] [DOI] (P p)