SbcC

From SubtiWiki
Revision as of 07:13, 17 June 2011 by JGerwig (talk | contribs) (Biological materials)
Jump to: navigation, search
  • Description: DNA exonuclease

Gene name sbcC
Synonyms yirY
Essential no
Product DNA exonuclease
Function DNA inter-strand cross-link repair
MW, pI 128 kDa, 5.294
Gene length, protein length 3390 bp, 1130 aa
Immediate neighbours sbcD, yisB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YirY context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA repair/ recombination, genetic competence

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU10650

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: SbcC subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: Nucleoid (Mid-cell) PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
    • GP894 (sbcCD::kan), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Peter Graumann, Freiburg University, Germany homepage

Your additional remarks

References

Reviews

Peter L Graumann, Tobias Knust
Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair.
Chromosome Res.: 2009, 17(2);265-75
[PubMed:19308706] [WorldCat.org] [DOI] (I p)

Original publications

Judita Mascarenhas, Humberto Sanchez, Serkalem Tadesse, Dawit Kidane, Mahalakshmi Krisnamurthy, Juan C Alonso, Peter L Graumann
Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repair.
BMC Mol. Biol.: 2006, 7;20
[PubMed:16780573] [WorldCat.org] [DOI] (I e)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J. Bacteriol.: 2002, 184(9);2344-51
[PubMed:11948146] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed