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  • Description: tRNA specific adenosine deaminase

Gene name yaaJ
Essential no
Product tRNA specific adenosine deaminase
Function tRNA modification
Gene expression levels in SubtiExpress: yaaJ
MW, pI 17 kDa, 5.636
Gene length, protein length 483 bp, 161 aa
Immediate neighbours yaaI, scr
Sequences Protein DNA DNA_with_flanks
Genetic context
YaaJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YaaJ expression.png

Categories containing this gene/protein


This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU00180

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)
  • Paralogous protein(s):
  • The corresponding gene in E. coli: EcoliWiki

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2B3J (the protein of Staphylococcus aureus, complex with RNA) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Takashi Inaoka, Takenori Satomura, Yasutaro Fujita, Kozo Ochi
Novel gene regulation mediated by overproduction of secondary metabolite neotrehalosadiamine in Bacillus subtilis.
FEMS Microbiol Lett: 2009, 291(2);151-6
[PubMed:19087206] [] [DOI] (I p)

Heather C Losey, Alexander J Ruthenburg, Gregory L Verdine
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA.
Nat Struct Mol Biol: 2006, 13(2);153-9
[PubMed:16415880] [] [DOI] (P p)

Jeannette Wolf, André P Gerber, Walter Keller
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli.
EMBO J: 2002, 21(14);3841-51
[PubMed:12110595] [] [DOI] (P p)