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  • Description: antitoxin RNA, inhibits bsrG translation and causes destabilization of the bsrG mRNA

Gene name SR4
Essential no
Product antitoxin RNA
Function inhibition of BsrG toxin expression
Gene length 180 bp
Immediate neighbours bsrG, yokL
Get the DNA sequence
Genetic context
File:BsrG context.gif
This image was kindly provided by SubtiList

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, SPß prophage, ncRNA

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

  • cell lysis on agar plates PubMed

Database entries

  • BsubCyc: ?
  • DBTBS entry: no entry
  • SubtiList entry: no entry
  • Structure:

Additional information


binds the bsrG mRNA and triggers its degradation PubMed, moreover SR4 inhibits bsrG translation PubMed

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:

Labs working on this gene/RNA

Sabine Brantl, Jena, Germany

Your additional remarks


Natalie Jahn, Sabine Brantl
One antitoxin--two functions: SR4 controls toxin mRNA decay and translation.
Nucleic Acids Res: 2013, 41(21);9870-80
[PubMed:23969414] [] [DOI] (I p)

Natalie Jahn, Heike Preis, Christoph Wiedemann, Sabine Brantl
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.
Mol Microbiol: 2012, 83(3);579-98
[PubMed:22229825] [] [DOI] (I p)