Difference between revisions of "Pdp"

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=The gene=
 
=The gene=

Revision as of 08:48, 23 June 2009

  • Description: pyrimidine nucleoside phosphorylase

Gene name pdp
Synonyms
Essential no
Product pyrimidine nucleoside phosphorylase
Function pyrimidine interconversion
Metabolic function and regulation of this protein in SubtiPathways:
Nucleoside catabolism, Nucleotides (regulation)
MW, pI 46 kDa, 4.765
Gene length, protein length 1299 bp, 433 aa
Immediate neighbours hutM, nupC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Pdp context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU39400

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate (according to Swiss-Prot)
  • Protein family: thymidine/pyrimidine-nucleoside phosphorylase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1BRW (Geobacillus stearothermophilus)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation: repressed by glucose (CcpA)
  • Regulatory mechanism: CcpA: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

X Zeng, A Galinier, H H Saxild
Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilis.
Microbiology (Reading, Engl.): 2000, 146 ( Pt 11);2901-8
[PubMed:11065368] [WorldCat.org] [DOI] (P p)

X Zeng, H H Saxild
Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis.
J. Bacteriol.: 1999, 181(6);1719-27
[PubMed:10074062] [WorldCat.org] (P p)

H H Saxild, L N Andersen, K Hammer
Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.
J. Bacteriol.: 1996, 178(2);424-34
[PubMed:8550462] [WorldCat.org] [DOI] (P p)