PdeH

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  • Description: c-di-GMP degrading phosphodiesterase

Gene name pdeH
Synonyms yuxH, comB, yufA
Essential no
Product c-di-GMP degrading phosphodiesterase
Function degradation of c-di-GMP
Gene expression levels in SubtiExpress: pdeH
MW, pI 47 kDa, 5.36
Gene length, protein length 1227 bp, 409 aa
Immediate neighbours yuzC, pncB
Sequences Protein DNA DNA_with_flanks
Genetic context
YuxH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YuxH expression.png















Categories containing this gene/protein

metabolism of signalling nucleotides, motility and chemotaxis

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU31740

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • degradation of c-di-GMP PubMed
  • Protein family: comB family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • contains an EAL domain PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP1590 (kan) available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J. Bacteriol.: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Yun Chen, Yunrong Chai, Jian-hua Guo, Richard Losick
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.
J. Bacteriol.: 2012, 194(18);5080-90
[PubMed:22821967] [WorldCat.org] [DOI] (I p)

Masaya Fujita, José Eduardo González-Pastor, Richard Losick
High- and low-threshold genes in the Spo0A regulon of Bacillus subtilis.
J. Bacteriol.: 2005, 187(4);1357-68
[PubMed:15687200] [WorldCat.org] [DOI] (P p)

Virginie Molle, Masaya Fujita, Shane T Jensen, Patrick Eichenberger, José E González-Pastor, Jun S Liu, Richard Losick
The Spo0A regulon of Bacillus subtilis.
Mol. Microbiol.: 2003, 50(5);1683-701
[PubMed:14651647] [WorldCat.org] [DOI] (P p)

Y Weinrauch, N Guillen, D A Dubnau
Sequence and transcription mapping of Bacillus subtilis competence genes comB and comA, one of which is related to a family of bacterial regulatory determinants.
J. Bacteriol.: 1989, 171(10);5362-75
[PubMed:2507523] [WorldCat.org] [DOI] (P p)