Difference between revisions of "NupC"

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=The gene=
 
=The gene=

Revision as of 08:47, 23 June 2009

  • Description: pyrimidine nucleoside transport protein

Gene name nupC
Synonyms
Essential no
Product pyrimidine nucleoside transport protein
Function pyrimidine uptake
Metabolic function and regulation of this protein in SubtiPathways:
Nucleoside catabolism, Nucleotides (regulation)
MW, pI 42 kDa, 9.316
Gene length, protein length 1179 bp, 393 aa
Immediate neighbours pdp, dra
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
NupC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU39410

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: SLC28A transporter family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot), membrane associated PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation: repressed by glucose (CcpA)
  • Regulatory mechanism: CcpA: transcription repression
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hannes Hahne, Susanne Wolff, Michael Hecker, Dörte Becher
From complementarity to comprehensiveness--targeting the membrane proteome of growing Bacillus subtilis by divergent approaches.
Proteomics: 2008, 8(19);4123-36
[PubMed:18763711] [WorldCat.org] [DOI] (I p)

X Zeng, A Galinier, H H Saxild
Catabolite repression of dra-nupC-pdp operon expression in Bacillus subtilis.
Microbiology (Reading, Engl.): 2000, 146 ( Pt 11);2901-8
[PubMed:11065368] [WorldCat.org] [DOI] (P p)

X Zeng, H H Saxild
Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis.
J. Bacteriol.: 1999, 181(6);1719-27
[PubMed:10074062] [WorldCat.org] (P p)

H H Saxild, L N Andersen, K Hammer
Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.
J. Bacteriol.: 1996, 178(2);424-34
[PubMed:8550462] [WorldCat.org] [DOI] (P p)