NrdI

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  • Description: ribonucleoside-diphosphate reductase

Gene name nrdI
Synonyms ymaA
Essential yes PubMed
Product ribonucleoside-diphosphate reductase
Function synthesis of deoxyribonucleoside triphosphates
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 14 kDa, 8.58
Gene length, protein length 390 bp, 130 aa
Immediate neighbours ymzA, nrdE
Gene sequence (+200bp) Protein sequence
Genetic context
YmaA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU17370

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: nrdI family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: distinct promoters for aerobic and anaerobic expression PubMed, anaerobic expression requires ResD PubMed
    • expressed under anaerobic conditions (ResD) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Elisabeth Härtig, Anja Hartmann, Manuela Schätzle, Alessandra M Albertini, Dieter Jahn
The Bacillus subtilis nrdEF genes, encoding a class Ib ribonucleotide reductase, are essential for aerobic and anaerobic growth.
Appl. Environ. Microbiol.: 2006, 72(8);5260-5
[PubMed:16885274] [WorldCat.org] [DOI] (P p)

C Scotti, A Valbuzzi, M Perego, A Galizzi, A M Albertini
The Bacillus subtilis genes for ribonucleotide reductase are similar to the genes for the second class I NrdE/NrdF enzymes of Enterobacteriaceae.
Microbiology (Reading, Engl.): 1996, 142 ( Pt 11);2995-3004
[PubMed:8969495] [WorldCat.org] [DOI] (P p)