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  • Description: RNase EndoA, MazF family toxin, cleaves cellular mRNAs at specific, but frequently occuring sites

Gene name ndoA
Synonyms ydcE
Essential no
Product endoribonuclease EndoA, MazF family toxin
Function plasmid partition
MW, pI 12 kDa, 4.892
Gene length, protein length 348 bp, 116 aa
Immediate neighbours ndoAI, rsbR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YdcE context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU04660

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: pemK family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Olivier Pellegrini, Nathalie Mathy, Arhonda Gogos, Lawrence Shapiro, Ciarán Condon
The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.
Mol. Microbiol.: 2005, 56(5);1139-48
[PubMed:15882409] [WorldCat.org] [DOI] (P p)