MciZ

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  • Description: FtsZ inhibition peptide

Gene name mciZ
Synonyms
Essential no
Product FtsZ inhibition peptide
Function inhibits GTPase activity of FtsZ and Z ring formation during sporulation
Interactions involving this protein in SubtInteract: MciZ
MW, pI 4.8 kDa, y.yy
Gene length, protein length 120 bp, 40 aa
Immediate neighbours nudF, yqkF
Gene sequence (+200bp) Protein sequence
Genetic context
NudF context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell division, short peptides

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: no entry

Additional information

This gene was only recently identified. PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: inhibits GTPase activity of FtsZ and Z ring formation during sporulation PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: no entry
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • expressed early during sporulation in the mother cell (SigE) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

David W Adams, Jeff Errington
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.
Nat. Rev. Microbiol.: 2009, 7(9);642-53
[PubMed:19680248] [WorldCat.org] [DOI] (I p)


Original Publications

Aaron A Handler, Joo Eun Lim, Richard Losick
Peptide inhibitor of cytokinesis during sporulation in Bacillus subtilis.
Mol. Microbiol.: 2008, 68(3);588-99
[PubMed:18284588] [WorldCat.org] [DOI] (I p)