HutI

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  • Description: imidazolone-5-propionate hydrolase

Gene name hutI
Synonyms
Essential no
Product imidazolone-5-propionate hydrolase
Function histidine utilization
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 45 kDa, 5.215
Gene length, protein length 1263 bp, 421 aa
Immediate neighbours hutU, hutG
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HutI context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU39370

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+ (according to Swiss-Prot)
  • Protein family: hutI family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Juliane Ollinger, Kyung-Bok Song, Haike Antelmann, Michael Hecker, John D Helmann
Role of the Fur regulon in iron transport in Bacillus subtilis.
J. Bacteriol.: 2006, 188(10);3664-73
[PubMed:16672620] [WorldCat.org] [DOI] (P p)