HutH

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  • Description: histidase

Gene name hutH
Synonyms
Essential no
Product histidase
Function histidine utilization
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 55 kDa, 5.221
Gene length, protein length 1524 bp, 508 aa
Immediate neighbours hutP, hutU
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HutH context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU39350

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-histidine = urocanate + NH3 (according to Swiss-Prot)
  • Protein family: PAL/histidase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP1114 (spc), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Juliane Ollinger, Kyung-Bok Song, Haike Antelmann, Michael Hecker, John D Helmann
Role of the Fur regulon in iron transport in Bacillus subtilis.
J. Bacteriol.: 2006, 188(10);3664-73
[PubMed:16672620] [WorldCat.org] [DOI] (P p)

S H Fisher, B Magasanik
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.
J. Bacteriol.: 1984, 158(1);379-82
[PubMed:6143742] [WorldCat.org] (P p)