Difference between revisions of "HisJ"

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=The gene=
 
=The gene=

Revision as of 16:56, 22 June 2009

  • Description: histidinol phosphate phosphatase

Gene name hisJ
Synonyms ytvP
Essential no
Product histidinol phosphate phosphatase
Function biosynthesis of histidine
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 30 kDa, 5.061
Gene length, protein length 804 bp, 268 aa
Immediate neighbours ezrA, yttP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HisJ context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU29620

Phenotypes of a mutant

auxotroph for histidine

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-histidinol phosphate + H2O = L-histidinol + phosphate (according to Swiss-Prot)
  • Protein family: HisK subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Stephane Aymerich, Microbiology and Molecular Genetics, INRA Paris-Grignon, France

Your additional remarks

References

D le Coq, S Fillinger, S Aymerich
Histidinol phosphate phosphatase, catalyzing the penultimate step of the histidine biosynthesis pathway, is encoded by ytvP (hisJ) in Bacillus subtilis.
J. Bacteriol.: 1999, 181(10);3277-80
[PubMed:10322033] [WorldCat.org] (P p)