Difference between revisions of "HisF"

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=The gene=
 
=The gene=

Revision as of 16:56, 22 June 2009

  • Description: cyclase-like protein

Gene name hisF
Synonyms
Essential no
Product cyclase-like protein
Function biosynthesis of histidine
Metabolic function and regulation of this protein in SubtiPathways:
His
MW, pI 27 kDa, 5.238
Gene length, protein length 756 bp, 252 aa
Immediate neighbours hisI, hisA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
HisF context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU34870

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O (according to Swiss-Prot)
  • Protein family: hisA/hisF family (according to Swiss-Prot)
  • Paralogous protein(s): HisA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J. Bacteriol.: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)