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  • Description: diguanylate cyclase

Gene name dgcP
Synonyms ytrP
Essential no
Product diguanylate cyclase
Function synthesis of c-di-GMP
Gene expression levels in SubtiExpress: dgcP
MW, pI 65 kDa, 5.695
Gene length, protein length 1737 bp, 579 aa
Immediate neighbours ytsP, rpsD
Sequences Protein DNA DNA_with_flanks
Genetic context
YtrP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YtrP expression.png

Categories containing this gene/protein

metabolism of signalling nucleotides

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU29650

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • synthesis of c-di-GMP from two molecules of GTP PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • contains an N-terminal GAF domain PubMed
    • contains a C-terminal GGDEF domain PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant: GP1591 (tet) available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J. Bacteriol.: 2013, 195(21);4782-92
[PubMed:23893111] [WorldCat.org] [DOI] (I p)

Yun Chen, Yunrong Chai, Jian-hua Guo, Richard Losick
Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis.
J. Bacteriol.: 2012, 194(18);5080-90
[PubMed:22821967] [WorldCat.org] [DOI] (I p)