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  • Description: carboxy-terminal processing serine protease, cleaves SpoIVFA, this results in processing of pro-SigK

Gene name ctpB
Synonyms yvjB
Essential no
Product carboxy-terminal processing serine protease,
cleaves SpoIVFA
Function control of SigK activation
Gene expression levels in SubtiExpress: ctpB
MW, pI 52 kDa, 8.641
Gene length, protein length 1440 bp, 480 aa
Immediate neighbours swrAA/2, ftsX
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YvjB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
CtpB expression.png

Categories containing this gene/protein

proteolysis, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigE regulon, SigG regulon

The gene

Basic information

  • Locus tag: BSU35240

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): CtpA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: ctpB (according to DBTBS)
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Nathalie Campo, David Z Rudner
SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis.
J. Bacteriol.: 2007, 189(16);6021-7
[PubMed:17557826] [WorldCat.org] [DOI] (P p)

Nathalie Campo, David Z Rudner
A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis.
Mol. Cell: 2006, 23(1);25-35
[PubMed:16818230] [WorldCat.org] [DOI] (P p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J. Mol. Biol.: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Qi Pan, Richard Losick, David Z Rudner
A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis.
J. Bacteriol.: 2003, 185(20);6051-6
[PubMed:14526016] [WorldCat.org] [DOI] (P p)