ComEC

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  • Description: late competence operon required for DNA binding and uptake

Gene name comEC
Synonyms comD
Essential no
Product unknown
Function compentence
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 86 kDa, 6.964
Gene length, protein length 2328 bp, 776 aa
Immediate neighbours holA, comEB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComEC context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU25570

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: post-translational control by ComN, yutB is required for transcription PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J. Bacteriol.: 2009, 191(3);949-58
[PubMed:19028902] [WorldCat.org] [DOI] (I p)

Naomi Kramer, Jeanette Hahn, David Dubnau
Multiple interactions among the competence proteins of Bacillus subtilis.
Mol. Microbiol.: 2007, 65(2);454-64
[PubMed:17630974] [WorldCat.org] [DOI] (P p)

Irena Draskovic, David Dubnau
Biogenesis of a putative channel protein, ComEC, required for DNA uptake: membrane topology, oligomerization and formation of disulphide bonds.
Mol. Microbiol.: 2005, 55(3);881-96
[PubMed:15661011] [WorldCat.org] [DOI] (P p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol. Lett.: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

J Hahn, G Inamine, Y Kozlov, D Dubnau
Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA.
Mol. Microbiol.: 1993, 10(1);99-111
[PubMed:7968523] [WorldCat.org] [DOI] (P p)