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  • Description: late competence protein required for DNA binding and uptake

Gene name comEB
Synonyms comD
Essential no
Product late competence protein
Function genetic compentence
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 20 kDa, 5.368
Gene length, protein length 567 bp, 189 aa
Immediate neighbours comEC, comEA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComEB context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU25580

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: post-translational control by ComN, yutB is required for transcription PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J. Bacteriol.: 2009, 191(3);949-58
[PubMed:19028902] [] [DOI] (I p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol. Lett.: 2002, 206(2);197-200
[PubMed:11814663] [] [DOI] (P p)

J Hahn, G Inamine, Y Kozlov, D Dubnau
Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA.
Mol. Microbiol.: 1993, 10(1);99-111
[PubMed:7968523] [] [DOI] (P p)