Difference between revisions of "ComEA"

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=The gene=
=The gene=

Revision as of 08:26, 23 June 2009

  • Description: exogenous DNA-binding protein

Gene name comEA
Synonyms comD
Essential no
Product exogenous DNA-binding protein
Function competence
Metabolic function and regulation of this protein in SubtiPathways:
Nucleotides (regulation)
MW, pI 21 kDa, 4.824
Gene length, protein length 615 bp, 205 aa
Immediate neighbours comEB, comER
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComEA context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU25590

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism: post-translational control by ComN, yutB is required for transcription PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Mitsuo Ogura, Teruo Tanaka
The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD).
J. Bacteriol.: 2009, 191(3);949-58
[PubMed:19028902] [WorldCat.org] [DOI] (I p)

Naomi Kramer, Jeanette Hahn, David Dubnau
Multiple interactions among the competence proteins of Bacillus subtilis.
Mol. Microbiol.: 2007, 65(2);454-64
[PubMed:17630974] [WorldCat.org] [DOI] (P p)

Inês Chen, Roberta Provvedi, David Dubnau
A macromolecular complex formed by a pilin-like protein in competent Bacillus subtilis.
J. Biol. Chem.: 2006, 281(31);21720-7
[PubMed:16751195] [WorldCat.org] [DOI] (P p)

Hanne Jarmer, Randy Berka, Steen Knudsen, Hans H Saxild
Transcriptome analysis documents induced competence of Bacillus subtilis during nitrogen limiting conditions.
FEMS Microbiol. Lett.: 2002, 206(2);197-200
[PubMed:11814663] [WorldCat.org] [DOI] (P p)

R Provvedi, D Dubnau
ComEA is a DNA receptor for transformation of competent Bacillus subtilis.
Mol. Microbiol.: 1999, 31(1);271-80
[PubMed:9987128] [WorldCat.org] [DOI] (P p)

G S Inamine, D Dubnau
ComEA, a Bacillus subtilis integral membrane protein required for genetic transformation, is needed for both DNA binding and transport.
J. Bacteriol.: 1995, 177(11);3045-51
[PubMed:7768800] [WorldCat.org] [DOI] (P p)

J Hahn, G Inamine, Y Kozlov, D Dubnau
Characterization of comE, a late competence operon of Bacillus subtilis required for the binding and uptake of transforming DNA.
Mol. Microbiol.: 1993, 10(1);99-111
[PubMed:7968523] [WorldCat.org] [DOI] (P p)