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Gene name comC
Essential no
Product processing protease
Function genetic transformation
MW, pI 26 kDa, 9.843
Gene length, protein length 744 bp, 248 aa
Immediate neighbours spoIIB, folC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ComC context.gif
This image was kindly provided by SubtiList

The gene

Basic information

  • Locus tag: BSU28070

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine (according to Swiss-Prot)
  • Protein family: peptidase A24 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cell membrane (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • ComK: transcription activation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Inês Chen, Roberta Provvedi, David Dubnau
A macromolecular complex formed by a pilin-like protein in competent Bacillus subtilis.
J Biol Chem: 2006, 281(31);21720-21727
[PubMed:16751195] [] [DOI] (P p)

Y S Chung, F Breidt, D Dubnau
Cell surface localization and processing of the ComG proteins, required for DNA binding during transformation of Bacillus subtilis.
Mol Microbiol: 1998, 29(3);905-13
[PubMed:9723928] [] [DOI] (P p)

Y S Chung, D Dubnau
ComC is required for the processing and translocation of comGC, a pilin-like competence protein of Bacillus subtilis.
Mol Microbiol: 1995, 15(3);543-51
[PubMed:7783624] [] [DOI] (P p)

D van Sinderen, A ten Berge, B J Hayema, L Hamoen, G Venema
Molecular cloning and sequence of comK, a gene required for genetic competence in Bacillus subtilis.
Mol Microbiol: 1994, 11(4);695-703
[PubMed:8196543] [] [DOI] (P p)

S Mohan, D Dubnau
Transcriptional regulation of comC: evidence for a competence-specific transcription factor in Bacillus subtilis.
J Bacteriol: 1990, 172(7);4064-71
[PubMed:1694528] [] [DOI] (P p)

S Mohan, J Aghion, N Guillen, D Dubnau
Molecular cloning and characterization of comC, a late competence gene of Bacillus subtilis.
J Bacteriol: 1989, 171(11);6043-51
[PubMed:2553669] [] [DOI] (P p)