Cmk

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  • Description: cytidylate kinase (CMP, dCMP)

Gene name cmk
Synonyms jofC, ypfC
Essential yes PubMed
Product cytidylate kinase (CMP, dCMP)
Function synthesis of CTP and dCTP
Metabolic function and regulation of this protein in SubtiPathways:
Pyrimidines, Nucleotides (regulation)
MW, pI 24 kDa, 4.999
Gene length, protein length 672 bp, 224 aa
Immediate neighbours ypfD, ypfB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Cmk context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU22890

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + (d)CMP = ADP + (d)CDP (according to Swiss-Prot)
  • Protein family: Type 1 subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

C P Schultz, L Ylisastigui-Pons, L Serina, H Sakamoto, H H Mantsch, J Neuhard, O Bârzu, A M Gilles
Structural and catalytic properties of CMP kinase from Bacillus subtilis: a comparative analysis with the homologous enzyme from Escherichia coli.
Arch. Biochem. Biophys.: 1997, 340(1);144-53
[PubMed:9126287] [WorldCat.org] [DOI] (P p)