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  • Description: hydrophobic toxin

Gene name bsrG
Essential no
Product toxin
Function unknown
MW, pI
Gene length, protein length 294 bp, 38 aa
Immediate neighbours yolA, SR4
Get the DNA and protein
Genetic context
File:BsrG context.gif
This image was kindly provided by SubtiList

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, SPß prophage, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • BsubCyc: ?
  • DBTBS entry: no entry
  • SubtiList entry: no entry

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • BsubCyc: ?
  • Structure:
  • UniProt:
  • KEGG entry:
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expression increases at the onset of the stationary phase PubMed
    • the mRNA is destabilized upon interaction with the antitoxin RNA SR4 PubMed
    • the mRNA is degraded by Rnc, Rny and Rnr PubMed
  • Regulatory mechanism:
    • the mRNA is degraded by Rnc, Rny and Rnr, degradation is enhanced at higher temperature PubMed
  • Additional information:
    • half-life of the mRNA: 15 min PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:

Labs working on this gene/protein

Sabine Brantl, Jena, Germany

Your additional remarks


Natalie Jahn, Sabine Brantl
One antitoxin--two functions: SR4 controls toxin mRNA decay and translation.
Nucleic Acids Res: 2013, 41(21);9870-80
[PubMed:23969414] [] [DOI] (I p)

Natalie Jahn, Heike Preis, Christoph Wiedemann, Sabine Brantl
BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.
Mol Microbiol: 2012, 83(3);579-98
[PubMed:22229825] [] [DOI] (I p)

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [] [DOI] (I p)

Shinichi Saito, Hiroshi Kakeshita, Kouji Nakamura
Novel small RNA-encoding genes in the intergenic regions of Bacillus subtilis.
Gene: 2009, 428(1-2);2-8
[PubMed:18948176] [] [DOI] (P p)