Difference between revisions of "BkdR"

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=The gene=
 
=The gene=

Revision as of 16:59, 22 June 2009

Gene name bkdR
Synonyms yqiR
Essential no
Product transcriptional activator (for SigL-dependent promoter))
Function regulation of branched-chain amino acid utilization,

required for survival at low temperatures)

MW, pI 77 kDa, 6.237
Gene length, protein length 2076 bp, 692 aa
Immediate neighbours ptb, yqzF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
BkdR context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU24100

Phenotypes of a mutant

The mutant is cold-sensitive PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
    • repressed during growth in the presence of branched chain amino acids (CodY) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Frank Wiegeshoff, Carsten L Beckering, Michel Debarbouille, Mohamed A Marahiel
Sigma L is important for cold shock adaptation of Bacillus subtilis.
J. Bacteriol.: 2006, 188(8);3130-3
[PubMed:16585774] [WorldCat.org] [DOI] (P p)

M Debarbouille, R Gardan, M Arnaud, G Rapoport
Role of bkdR, a transcriptional activator of the sigL-dependent isoleucine and valine degradation pathway in Bacillus subtilis.
J. Bacteriol.: 1999, 181(7);2059-66
[PubMed:10094682] [WorldCat.org] (P p)