Difference between revisions of "BacF"
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' | + | * '''[[SubtInteract|Interactions]]:''' |
* '''Localization:''' cytoplasm (according to Swiss-Prot) | * '''Localization:''' cytoplasm (according to Swiss-Prot) | ||
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* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[CodY]]: transcription repression {{PubMed|12372825}} | + | ** [[CodY]]: transcription repression {{PubMed|12372825,21709425}} |
| − | ** [[AbrB]]: transcription repression {{PubMed|12697329}} | + | ** [[AbrB]]: transcription repression {{PubMed|12697329,21709425}} |
** [[ScoC]]: transcription repression {{PubMed|19801406}} | ** [[ScoC]]: transcription repression {{PubMed|19801406}} | ||
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=References= | =References= | ||
| − | '''Additional publications:''' {{PubMed|12697329}} | + | '''Additional publications:''' {{PubMed|12697329,21709425}} |
<pubmed> 12372825 19801406 20052993 </pubmed> | <pubmed> 12372825 19801406 20052993 </pubmed> | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 17:31, 13 July 2011
- Description: aminotransferase involved in bacilysin synthesis
| Gene name | bacF |
| Synonyms | ywfG, ipa-85d |
| Essential | no |
| Product | aminotransferase |
| Function | biosynthesis of the antibiotic bacilysin |
| MW, pI | 44 kDa, 5.347 |
| Gene length, protein length | 1197 bp, 399 aa |
| Immediate neighbours | ywfH, bacE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
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Contents
Categories containing this gene/protein
miscellaneous metabolic pathways, biosynthesis of antibacterial compounds
This gene is a member of the following regulons
AbrB regulon, CodY regulon, ScoC regulon
The gene
Basic information
- Locus tag: BSU37690
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: YwfG catalyzes transamination of tetrahydro-4-hydroxyphenylpyruvate (with L-Phe as amino donor), to form tetrahydrotyrosine PubMed
- Protein family: class-I pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P39643
- KEGG entry: [2]
- E.C. number: 2.6.1.1
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Sarah A Mahlstedt, Christopher T Walsh
Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis.
Biochemistry: 2010, 49(5);912-23
[PubMed:20052993]
[WorldCat.org]
[DOI]
(I p)
Takashi Inaoka, Guojun Wang, Kozo Ochi
ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
J Bacteriol: 2009, 191(23);7367-71
[PubMed:19801406]
[WorldCat.org]
[DOI]
(I p)
Takashi Inaoka, Kosaku Takahashi, Mayumi Ohnishi-Kameyama, Mitsuru Yoshida, Kozo Ochi
Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis.
J Biol Chem: 2003, 278(4);2169-76
[PubMed:12372825]
[WorldCat.org]
[DOI]
(P p)
