ArsB

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  • Description: extrusion of arsenite

Gene name arsB
Synonyms yqcL
Essential no
Product arsenite exporter
Function detoxification of arsenate and arsenite
Metabolic function and regulation of this protein in SubtiPathways:
metal ion homeostasis
MW, pI 38 kDa, 9.773
Gene length, protein length 1038 bp, 346 aa
Immediate neighbours arsC, yqcK
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ArsB context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

transporters/ other, resistance against toxic metals, Skin element

This gene is a member of the following regulons

ArsR regulon, SigF regulon

The gene

Basic information

  • Locus tag: BSU25790

Expression

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ACR3 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed early during sporulation in the forespore (SigF) PubMed
    • expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) (ArsR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J. Mol. Biol.: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J. Bacteriol.: 1998, 180(7);1655-61
[PubMed:9537360] [WorldCat.org] [DOI] (P p)