Difference between revisions of "AroH"

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=The gene=
 
=The gene=

Revision as of 08:20, 23 June 2009

  • Description: chorismate mutase (isozymes 1 and 2)

Gene name aroH
Synonyms
Essential no
Product chorismate mutase (isozymes 1 and 2)
Function biosynthesis of aromatic amino acids
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 14 kDa, 5.524
Gene length, protein length 381 bp, 127 aa
Immediate neighbours trpE, aroB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AroH context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU22690

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Chorismate = prephenate (according to Swiss-Prot)
  • Protein family: BCKDHA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • Structure: 2CHT (complex with a transition state analog), 1DBF
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Y M Chook, H Ke, W N Lipscomb
Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc. Natl. Acad. Sci. U.S.A.: 1993, 90(18);8600-3
[PubMed:8378335] [WorldCat.org] [DOI] (P p)