AroD

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  • Description: shikimate dehydrogenase

Gene name aroD
Synonyms
Essential no
Product shikimate dehydrogenase
Function biosynthesis of aromatic amino acids
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 30 kDa, 6.077
Gene length, protein length 840 bp, 280 aa
Immediate neighbours yqeI, yqeH
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AroD context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU25660

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Shikimate + NADP+ = 3-dehydroshikimate + NADPH (according to Swiss-Prot)
  • Protein family: shikimate dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

J Bergsma, K E Meihuizen, W Van Oeveren, W N Konings
Restoration of NADH oxidation with menaquinones and menaquinone analogues in membrane vesicles from the menaquinone-deficient Bacillus subtilis aroD.
Eur. J. Biochem.: 1982, 125(3);651-7
[PubMed:6811271] [WorldCat.org] [DOI] (P p)