Apt

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  • Description: adenine phosphoribosyltransferase

Gene name apt
Synonyms
Essential no
Product adenine phosphoribosyltransferase
Function purine salvage and interconversion
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Purine synthesis, Nucleotides (regulation)
MW, pI 18 kDa, 4.701
Gene length, protein length 510 bp, 170 aa
Immediate neighbours relA, yrvE
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Apt context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU27610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)
  • Protein family: purine/pyrimidine phosphoribosyltransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

H H Saxild, P Nygaard
Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs.
J. Bacteriol.: 1987, 169(7);2977-83
[PubMed:3110131] [WorldCat.org] [DOI] (P p)