Adk

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  • Description: adenylate kinase

Gene name adk
Synonyms
Essential yes PubMed
Product adenylate kinase
Function ADP formation
Metabolic function and regulation of this protein in SubtiPathways:
Purine salvage, Nucleotides (regulation)
MW, pI 23 kDa, 4.449
Gene length, protein length 651 bp, 217 aa
Immediate neighbours secY, map
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Adk context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU01370

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + AMP = 2 ADP (according to Swiss-Prot)
  • Protein family: adenylate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Rafael Couñago, Corey J Wilson, Matthew I Peña, Pernilla Wittung-Stafshede, Yousif Shamoo
An adaptive mutation in adenylate kinase that increases organismal fitness is linked to stability-activity trade-offs.
Protein Eng. Des. Sel.: 2008, 21(1);19-27
[PubMed:18093993] [WorldCat.org] [DOI] (P p)

J W Suh, S A Boylan, S H Oh, C W Price
Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region.
Gene: 1996, 169(1);17-23
[PubMed:8635744] [WorldCat.org] [DOI] (P p)