CdaS

• Description: maybe involved in the synthesis of c-di-AMP in vegetative cells
  
  

Gene name	yojJ
Synonyms
Essential	no
Product	unknown
Function	unknown
Gene expression levels in SubtiExpress: yojJ
MW, pI	22 kDa, 5.367
Gene length, protein length	621 bp, 207 aa
Immediate neighbours	yojK, yojI
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

metabolism of signalling nucleotides

The gene

Basic information

• Locus tag: BSU19430

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YbbP

Extended information on the protein

• Kinetic information:

• Domains: contains a DAC domain potentially involved in the synthesis of c-di-AMP PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 2FB5 (the protein of B. cereus, 48% identity, 81% similarity)

• UniProt: O31854

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: yojJ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • GP983 (yojJ::ermC), available in Stülke lab
  • GP1360 (yojJ::spc), available in Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Ute Römling
Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea.
Sci Signal: 2008, 1(33);pe39
[PubMed:18714086] [WorldCat.org] [DOI] (I e)

Original publications

Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650] [WorldCat.org] [DOI] (I p)