opuCB

168

glycine betaine/carnitine/choline/arsenobetaine/arsenocholine ABC transporter

Locus: BSU_33820

Molecular weight: 23.00 kDa

Isoelectric point: 9.7

Protein length: 217 aa

Gene length: 654 bp

Function: compatible solute transport

Product: glycine betaine/carnitine/choline/arsenobetaine/arsenocholine ABC transporter

Essential: no

Synonyms: opuCB, yvbD

Genomic Context

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List of homologs in different organisms, belongs to COG1174 (Galperin et al., 2021)

Gene

Coordinates: 3,469,184  3,469,837

The protein

Catalyzed reaction/ biological activity

• uptake of glycine betaine, arsenocholine and arsenobetaine PubMed

Protein family

• Binding-protein-dependent transport system permease family (according to UniProt)
• CysTW subfamily (according to UniProt)

Domains

• ABC transmembrane type-1 domain (aa 19-198) (according to UniProt)

Structure

• O34878 (AlphaFold)

Paralogous protein(s)

• OpuBB

Localization

• cell membrane PubMed

Expression and Regulation

Operons

• Genes: opuCA-opuCB-opuCC-opuCD

  Description: PubMed

  Regulation

  • induced by salt stress PubMed
  • induced in the absence of RnpM PubMed

  Regulatory mechanism

  • OpcR: repression, (sterical interference with RNA polymerase access) PubMed, in opcR regulon
  • RemA: activation, PubMed, in remA regulon
  • RnpM: unknown, PubMed, in rnpM regulon

Biological materials

Mutant

• BKE33820 (opuCB::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTAAAAGAGCTCCTCC,  downstream forward: _UP4_TCGTAAGGAGTTGGCACTGT
• BKK33820 (opuCB::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTTAAAAGAGCTCCTCC,  downstream forward: _UP4_TCGTAAGGAGTTGGCACTGT

References

Reviews

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Original Publications

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