yvrG

yvrG
168

two-component sensor kinase of the YvrG-YvrHb two-component system

locus
BSU_33210
Molecular weight
66.58 kDa
pI
9.52
Protein length
Gene length
function
regulation cell surface maintenance
product
two-component sensor histidine kinase
essential
no
ec
null
synonyms
yvrG

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0642 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,406,614  3,408,356
Phenotypes of a mutant
unusual autolysis and higher susceptibility to cell envelope antibiotics (bacitracin, aztreonam, cefepime, fosfomycin)  [Pubmed|16306698]
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The protein
Catalyzed reaction/ biological activity
autophosphorylation, phosphorylation of the [protein|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb] response regulator  [Pubmed|16306698]
ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)
[wiki|Domains]
two transmembrane segments
[wiki|Histidine kinase domain] (aa 363-580) (according to UniProt)
Structure
[AF|O34989]
Modification
autophosphorylation on a His residue
Paralogous protein(s)
[protein|9E8A6AB3920BFBFDAAD1F2E4F333A32354ABB25B|ykoH], [protein|1582E81F7DA85F38D6732D341ABD0F052587F25A|kinE], [protein|4EE48E4931F662E51586DB6D01E91C688329222D|cssS], [protein|52BB660B0CAB36C74F1D47963235846B45AF78AB|yclK]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb]-[gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]-[gene|0F65F634368E935585FC015BA64085F3A2244F9B|yvrE]
description
[Pubmed|22383849]
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[gene|7098319D8E88FDC2A629A3F4A21507FD7A649385|yvrHb]→[gene|0F65F634368E935585FC015BA64085F3A2244F9B|yvrE]

2024-02-27 04:16:50

Jstuelk

64

7b1ca7d9926202cb67b2f5ca02dc23abca36fbb6

F9AB94FC785A9E813163AC0107521543FD5405BF

Biological materials
Mutant
MGNA-B049 (yvrG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1048 NBRP B. subtilis, Japan]
BKE33210 ([gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33210 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCTCATGACCGCTTGCCTTC,  downstream forward: _UP4_TAAACATCAAGTGGTTTGGA
BKK33210 ([gene|96E4470EF4B558F4EC318FEBF58B779BA50DB7E2|yvrG]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33210 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCTCATGACCGCTTGCCTTC,  downstream forward: _UP4_TAAACATCAAGTGGTTTGGA
References
10094672,18820022,16306698

96E4470EF4B558F4EC318FEBF58B779BA50DB7E2

Page visits: 1967

Time of last update: 2024-03-29 02:14:54

Author of last update: Melvin.boenninger