YugK

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  • Description: similar to NADH-dependent butanol dehydrogenase

Gene name yugK
Synonyms
Essential no
Product unknown
Function unknown
Gene expression levels in SubtiExpress: yugK
MW, pI 43 kDa, 4.642
Gene length, protein length 1170 bp, 390 aa
Immediate neighbours pgi, yugJ
Sequences Protein DNA DNA_with_flanks
Genetic context
YugK context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YugK expression.png

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Categories containing this gene/protein

poorly characterized/ putative enzymes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU31360

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: iron-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s): YugJ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Laura R Jarboe
YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals.
Appl. Microbiol. Biotechnol.: 2011, 89(2);249-57
[PubMed:20924577] [WorldCat.org] [DOI] (I p)

Original publications

B Oudega, G Koningstein, L Rodrigues, M de Sales Ramon, H Hilbert, A Düsterhöft, T M Pohl, T Weitzenegger
Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).
Microbiology (Reading, Engl.): 1997, 143 ( Pt 8);2769-74
[PubMed:9274030] [WorldCat.org] (P p)

The corresponding protein in E. coli

Changhan Lee, Insook Kim, Junghoon Lee, Kang-Lok Lee, Bumchan Min, Chankyu Park
Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12.
J. Bacteriol.: 2010, 192(16);4205-14
[PubMed:20543070] [WorldCat.org] [DOI] (I p)

José Manuel Pérez, Felipe A Arenas, Gonzalo A Pradenas, Juan M Sandoval, Claudio C Vásquez
Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes.
J. Biol. Chem.: 2008, 283(12);7346-53
[PubMed:18211903] [WorldCat.org] [DOI] (P p)

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