yqgN

yqgN
168

5,10-methenyltetrahydrofolate synthetase, 5-formyltetrahydrofolate cyclo-ligase paralog implicated in thiamin metabolism

locus
BSU_24890
Molecular weight
21.27 kDa
pI
5.79
Protein length
Gene length
function
detoxification of 5-formyl-THF
product
5,10-methenyltetrahydrofolate synthetase
essential
no
ec
null
synonyms
yqgN

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0212 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,573,760 → 2,574,323
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The protein
Catalyzed reaction/ biological activity
converts toxic 5-formyl-THF (side product of [protein|BAE8062DA8538C9C83FFBA9684BECE9613EEFD2F|glyA]) back to 5,10-methenyl-THF [pubmed|21538139]
Protein family
5-formyltetrahydrofolate cyclo-ligase family (single member, according to UniProt)
Structure
[PDB|1YDM]
[AF|P54491]
Biological materials
Mutant
MGNA-C460 (yqgN::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2458 NBRP B. subtilis, Japan]
BKE24890 (Δ[gene|CB9728D2A23C8F03104FF781D514CB3E6169835E|yqgN]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTCTCATCCCCCTCGGA,  downstream forward: _UP4_TAACTTTCCTGTCCCTTATT
BKK24890 (Δ[gene|CB9728D2A23C8F03104FF781D514CB3E6169835E|yqgN]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATCTCTCATCCCCCTCGGA,  downstream forward: _UP4_TAACTTTCCTGTCCCTTATT
Original Publications
21538139

CB9728D2A23C8F03104FF781D514CB3E6169835E

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Time of last update: 2024-03-25 18:53:06

Author of last update: Jstuelk