yngA

yngA
168

flippase, transports the glucose-phosphate moiety of C55-P-Glc across the membrane

locus
BSU_18170
Molecular weight
16.52 kDa
pI
9.15
Protein length
Gene length
function
glycosylation of teichoic acids
product
flippase for teichoic acid glycosylation
essential
no
synonyms
yngA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2246 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,946,249 → 1,946,695
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The protein
Protein family
GtrA family (with [protein|FD30C4E458E63E8D6A932B351D4224F1AACD4B1B|gtcA], according to UniProt)
Structure
[PDB|5MLZ] (from Pyrococcus furiosus, 20% identity) [pubmed|28743912]
[AF|O31821]
[wiki|Localization]
cell membrane (according to UniProt)
Expression and Regulation
Operons
genes
[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]-[gene|69C5D9EF7ED43BCAB7A9D6148EDD323CE72F8E3D|yngB]-[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]
description
[Pubmed|20512483]
regulation
expression during spore [wiki|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]
expressed under anaerobic conditions ([protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]) [pubmed|33556370]
regulatory mechanism
[protein|706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ]: activation, [Pubmed|20512483], in [regulon|protein:706983E6942E883D3A9D45693E7B4015AEABE60B|yclJ regulon]
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[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]→[gene|289828D37CF5422908316ED2EF1AEAE76F84161D|uptA]

2024-03-03 16:08:58

Jstuelk

53

88307FFF5FF9989AB866CACFBDDAC58DEBA95B75

5BCC47A83DF8D622363F1295C3E4510BBE79F88C

Biological materials
Mutant
MGNA-B395 (yngA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1394 NBRP B. subtilis, Japan]
BKE18170 (Δ[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE18170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTTGTTGATATGGATT,  downstream forward: _UP4_ATACAGGATCAGGAGTGAAG
BKK18170 (Δ[gene|CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD|yngA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK18170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATTTGTTGATATGGATT,  downstream forward: _UP4_ATACAGGATCAGGAGTGAAG
References
20512483,27766092,28743912

CBCBF948979D9D63CBA86A9ED865E43B1F85A0AD

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Time of last update: 2024-03-28 12:23:10

Author of last update: Jstuelk