aerA

aerA
168

transcription activator, amino acid export regulator A (AraC family)

locus
BSU_05150
Molecular weight
34.07 kDa
pI
6.87
Protein length
Gene length
function
control of amino acid export
product
amino acid export regulator A
essential
no
ec
null
synonyms
ydeC

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG2207 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
561,514  562,389
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The protein
Catalyzed reaction/ biological activity
the protein is inactive under most conditions, if activated (either by mutations or by 2,3-diaminopropionic acid) activation of [gene|3BD05DE3ED5B293980F47EB621C54C7339F78DC7|aexA] expression [pubmed|38470260]
Protein family
[wiki|AraC family]
[wiki|Domains]
[wiki|HTH araC/xylS-type domain] (aa 191-289) (according to UniProt)
Structure
[AF|P96660]
Expression and Regulation
Operons
genes
[gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA]-[gene|CBEB1C62D727CF320E82C3ED636894B50F11E0AE|ydzE]
description
[pubmed|22383849]
sigma factors
[protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]: sigma factor, [Pubmed|11532142], in [regulon|protein:580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB regulon]
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[gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA]->[gene|CBEB1C62D727CF320E82C3ED636894B50F11E0AE|ydzE]

2024-03-28 10:15:58

Bzhu

45

59bc0174fd3aef20a892bb083ff6607114d252b5

61AFF2F491CBF04495E610BD7F03138B1FEF0965

Biological materials
Mutant
GP4117 (trpC2 [gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA] Y179D), available in [wiki|Jörg Stülke]'s lab [pubmed|38470260]
GP4119 (trpC2 [gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA] L122W), available in [wiki|Jörg Stülke]'s lab [pubmed|38470260]
MGNA-C079 (ydeC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2077 NBRP B. subtilis, Japan]
BKE05150 ([gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE05150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTGACTTCACACCTCA,  downstream forward: _UP4_TAAAGTTTATTCTATTAATA
BKK05150 ([gene|24A86A4846187E6026A2B7645DC4B7C70908942E|aerA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK05150 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATTCTGACTTCACACCTCA,  downstream forward: _UP4_TAAAGTTTATTCTATTAATA
lacZ fusion
GP4439, kana, (based on [wiki|pAC7]), available in [wiki|Jörg Stülke]'s lab [pubmed|38470260]
GP4441, cat, (based on [wiki|pAC5]), available in [wiki|Jörg Stülke]'s lab
References
23504016,38470260

24A86A4846187E6026A2B7645DC4B7C70908942E

Page visits: 1897

Time of last update: 2024-03-27 12:07:26

Author of last update: Jstuelk