spoVAB

168

essential for the uptake of the 1:1 chelate of pyridine-2,6-dicarboxylic acid (DPA(2,6)) and Ca(2+) into developing spores, required for spore maturation

locus: BSU_23430

Molecular weight: 15.08 kDa

pI: 10.12

Protein length: 141 aa

Gene length: 426 bp

function: spore maturation

product: unknown

essential: no

ec: null

synonyms: spoVAB

List of homologs in different organisms, belongs to COG5835 (Galperin et al., 2021)

Gene

Coordinates: 2,442,269 → 2,442,694

Phenotypes of a mutant

• the mutant initiates DPA release during germination faster than the wild type [pubmed|35654455]
• partially impaired localization of the [protein|9531F0A0DC4AE5696FFBAC9C2A773F15840E3255|spoVAD] "plug" in the spore inner membrane [pubmed|35654455]

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The protein

Structure

• [AF|P40867]

[wiki|Localization]

• cell membrane (according to UniProt)

Biological materials

Mutant

• BKE23430 (Δ[gene|AEC70413BDC29F435776D532E7049AA9A0BD893D|spoVAB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCCGACAAAAATGATGAACA,  downstream forward: _UP4_GACCATTCATAAGGAGGTTT
• BKK23430 (Δ[gene|AEC70413BDC29F435776D532E7049AA9A0BD893D|spoVAB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23430 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CCCGACAAAAATGATGAACA,  downstream forward: _UP4_GACCATTCATAAGGAGGTTT

labs

• [wiki|Peter Setlow], University of Connecticut Health Center, USA

References

Reviews

• 35638784

Original Publications

• 3114420,11751839,15451103,3926949,17158659,6432957,7934830,15699190,1903432,8755877,22328679,21398556,35654455,37777474