sigO

168

[wiki|RNA polymerase] [wiki|sigma factor] SigO (with [protein|AE8D4F07EFB17DA727D80229C3E72075928AA352|rsoA])

locus: BSU_33230

Molecular weight: 22.54 kDa

pI: 9.78

Protein length: 177 aa

Gene length: 531 bp

function: [wiki|RNA polymerase] [wiki|sigma factor]

product: co-sigma factor with [protein|AE8D4F07EFB17DA727D80229C3E72075928AA352|rsoA]

essential: no

synonyms: sigO, yvrI

List of homologs in different organisms, belongs to COG1191 (Galperin et al., 2021)

Gene

Coordinates: 3,409,462 → 3,409,992

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The protein

Protein family

• [wiki|Sigma-70 factor family] (according to UniProt)

[wiki|Domains]

• contains a DNA-binding helix-turn-helix motif (HTH) and the region 4.2 of Sigma factors [Pubmed|19940246]

Structure

• [AF|O34843]

Biological materials

Mutant

• MGNA-B052 (yvrI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1051 NBRP B. subtilis, Japan]
• BKE33230 (Δ[gene|6359025A73C0BD313F5BCC6F56FE88B820902AAA|sigO]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE33230 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATGCTTCATTATCTCCTTAC,  downstream forward: _UP4_CAAAAAAAGGGGGAAAAGTA
• BKK33230 (Δ[gene|6359025A73C0BD313F5BCC6F56FE88B820902AAA|sigO]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK33230 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATGCTTCATTATCTCCTTAC,  downstream forward: _UP4_CAAAAAAAGGGGGAAAAGTA

labs

• [wiki|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]

References

• 18573182,19047353,26651345,16306698,19940246,26367498,26400263,27558998