S4 RNA-binding domain

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The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterised, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA.

Proteins containing this domain

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Important references

L Aravind, E V Koonin
Novel predicted RNA-binding domains associated with the translation machinery.
J. Mol. Evol.: 1999, 48(3);291-302
[PubMed:10093218] [WorldCat.org] [DOI] (P p)

C Davies, R B Gerstner, D E Draper, V Ramakrishnan, S W White
The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.
EMBO J.: 1998, 17(16);4545-58
[PubMed:9707415] [WorldCat.org] [DOI] (P p)


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