rpsL

rpsL
168

ribosomal protein uS12

locus
BSU_01100
Molecular weight
15.00 kDa
pI
11
Protein length
Gene length
function
translation
product
ribosomal protein S12 (uS12)
essential
yes
synonyms
rpsL, strA, fun

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0048 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
129,702  130,118
Phenotypes of a mutant
essential [Pubmed|23002217,12682299]
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The protein
Protein family
Universal [wiki|ribosomal protein] uS12 family (single member, according to UniProt)
Structure
[PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
[AF|P21472]
Modification
phosphorylated on Arg-123 [Pubmed|22517742]
[wiki|Localization]
[wiki|ribosome] (according to UniProt)
Expression and Regulation
Operons
genes
[gene|11D7ABA61FC4069B48614875AF2C6C694291B545|rplGB]-[gene|0E4CB387626F53E5F60C7639D525B57D50C65C03|rpsL]-[gene|8049CACE85B2627A08CB4D8A8587D52E2DB24C7F|rpsG]-[gene|297844645CCCF40CB40E84339997F6610883DF4E|fusA]-[gene|E771685D6D41D48E0C0AF77F15B4F380820FCDC2|tufA]
description
[pubmed|22383849]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
the mRNA is processed between [gene|11D7ABA61FC4069B48614875AF2C6C694291B545|rplGB] and [gene|0E4CB387626F53E5F60C7639D525B57D50C65C03|rpsL] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]
regulatory mechanism
stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]
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[gene|11D7ABA61FC4069B48614875AF2C6C694291B545|rplGB]->[gene|E771685D6D41D48E0C0AF77F15B4F380820FCDC2|tufA]

2024-03-19 10:23:48

Jstuelk

69

d846304cc2bd15e30cde627ac53b7d142c24fbb5

614BD7852C60161107389373FB106F44BAE4C835

References
36815589,19653700,11489846,16391027,22517742,23002217,23912278,25903689,28468753,29794222,33368752

0E4CB387626F53E5F60C7639D525B57D50C65C03

Page visits: 5991

Time of last update: 2024-03-28 20:08:03

Author of last update: Jstuelk