rpsG

168

ribosomal protein uS7

locus: BSU_01110

Molecular weight: 17.00 kDa

pI: 10

Protein length: 156 aa

Gene length: 471 bp

function: translation

product: ribosomal protein S7 (uS7)

essential: yes

synonyms: rpsG

List of homologs in different organisms, belongs to COG0049 (Galperin et al., 2021)

Gene

Coordinates: 130,160  130,630

Phenotypes of a mutant

• essential [Pubmed|23002217,12682299]

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The protein

Protein family

• Universal [wiki|ribosomal protein] uS7 family (single member, according to UniProt)

Structure

• [PDB|1HUS] (Geobacillus stearothermophilus)
• [PDB|3J9W] (the [wiki|ribosome]) [Pubmed|25903689]
• [AF|P21469]

Modification

• phosphorylated on Arg-10 [Pubmed|22517742]

[wiki|Localization]

• [wiki|ribosome] (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|11D7ABA61FC4069B48614875AF2C6C694291B545|rplGB]-[gene|0E4CB387626F53E5F60C7639D525B57D50C65C03|rpsL]-[gene|8049CACE85B2627A08CB4D8A8587D52E2DB24C7F|rpsG]-[gene|297844645CCCF40CB40E84339997F6610883DF4E|fusA]-[gene|E771685D6D41D48E0C0AF77F15B4F380820FCDC2|tufA]

  description: [pubmed|22383849]

  regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • the mRNA is processed between [gene|11D7ABA61FC4069B48614875AF2C6C694291B545|rplGB] and [gene|0E4CB387626F53E5F60C7639D525B57D50C65C03|rpsL] by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y], this requires the [protein|EE52DFA35B935E551871D079A9BE877DB2001A3B|ricA]-[protein|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[protein|EBD15C174A03B7FCDFFE4C5DB5D86E93F1B9CAC4|ricT] complex [Pubmed|29794222]

  regulatory mechanism

  • stringent response: negative regulation, [pubmed|11948165], in [regulon|other_regulator:stringent response|stringent response]

References

• 36815589,19653700,22517742,23002217,25903689,37205477