RoxS

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  • Description: small RNA, controls expression of ppnKB and sucC-sucD

Gene name roxS
Synonyms rsaE
Essential no
Product trans-acting regulatory RNA
Function control of ppnKB and sucC-sucD expression
Gene length
Immediate neighbours yizD, yjbH
Gene sequence (+200bp)
Genetic context

Contents









Categories containing this gene/protein

ncRNA

This gene is a member of the following regulons

ResD regulon

The RoxS regulon

The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • BsubCyc: no entry
  • DBTBS entry: no entry
  • SubtiList entry: no entry
  • Structure:

Additional information

  • Similar RNA:

The RNA

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: hybridizes to ppnKB and sucD mRNAs to inhibit their translation and to destabilize them PubMed

Extended information on the RNA

  • Kinetic information

Database entries

  • BsubCyc: ?
  • Structure:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • the roxS RNA is degraded by the joined activities of RNase Y (initial endonucleolytic cleavage) and RNase J1 (processive degradation) PubMed
    • the roxS-ppnKB and roxS-sucC RNA duplexes form a cleavage site for RNase III PubMed

Biological materials

  • lacZ fusion:


Labs working on this gene/RNA

Ciaran Condon, Paris

Your additional remarks

References

Sylvain Durand, Frédérique Braun, Efthimia Lioliou, Cédric Romilly, Anne-Catherine Helfer, Laurianne Kuhn, Noé Quittot, Pierre Nicolas, Pascale Romby, Ciarán Condon
A nitric oxide regulated small RNA controls expression of genes involved in redox homeostasis in Bacillus subtilis.
PLoS Genet.: 2015, 11(2);e1004957
[PubMed:25643072] [WorldCat.org] [DOI] (I e)

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