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  • Description: part of haem translocase, required for cytochrome c synthesis

Gene name resB
Synonyms ypxB
Essential yes PubMed
Product part of the ResB-ResC haem translocase
Function cytochrome c biogenesis
Gene expression levels in SubtiExpress: resB
Interactions involving this protein in SubtInteract: ResB
Metabolic function and regulation of this protein in SubtiPathways:
MW, pI 61 kDa, 9.474
Gene length, protein length 1626 bp, 542 aa
Immediate neighbours resC, resA
Sequences Protein DNA DNA_with_flanks
Genetic context
ResB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ResB expression.png


Categories containing this gene/protein

respiration, essential genes, membrane proteins

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, ResD regulon

The gene

Basic information

  • Locus tag: BSU23140

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
    • expressed under conditions of phosphate limitation (PhoP) PubMed
    • repressed by glucose (CcpA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks


Umesh Ahuja, Peter Kjelgaard, Benjamin L Schulz, Linda Thöny-Meyer, Lars Hederstedt
Haem-delivery proteins in cytochrome c maturation System II.
Mol. Microbiol.: 2009, 73(6);1058-71
[PubMed:19682263] [] [DOI] (I p)

Soo-Keun Choi, Milton H Saier
Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis.
J. Mol. Microbiol. Biotechnol.: 2006, 11(1-2);104-10
[PubMed:16825793] [] [DOI] (P p)

M M Nakano, Y Zhu
Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth.
J. Bacteriol.: 2001, 183(6);1938-44
[PubMed:11222591] [] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol. Microbiol.: 2000, 36(3);638-50
[PubMed:10844653] [] (P p)

S M Birkey, W Liu, X Zhang, M F Duggan, F M Hulett
Pho signal transduction network reveals direct transcriptional regulation of one two-component system by another two-component regulator: Bacillus subtilis PhoP directly regulates production of ResD.
Mol. Microbiol.: 1998, 30(5);943-53
[PubMed:9988472] [] (P p)

G Sun, E Sharkova, R Chesnut, S Birkey, M F Duggan, A Sorokin, P Pujic, S D Ehrlich, F M Hulett
Regulators of aerobic and anaerobic respiration in Bacillus subtilis.
J. Bacteriol.: 1996, 178(5);1374-85
[PubMed:8631715] [] (P p)

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